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  Multiple Sclerosis Treatments

What drug treatments are available for MS and its symptoms?

Below is a table of drugs used to treat multiple sclerosis and its symptoms. It only lists drug therapies and does not deal with other forms of therapy - These shall be posted to this section in a short period of time.

It is vital that you are prescribed and take any of these medications in consultation with a fully qualified medical practitioner who is familiar with your case history. Many of these drugs have potentially serious side-effects especially in combination with other medications.

The list is by no means complete and new treatments are being researched and coming into use all the time. It should be emphasized that none of these drugs are a "cure" for either MS nor for any of its symptoms. The only medications available at the moment either slow down the course of the disease at best or are palliative on its symptoms.
 
 

ABC Treatments

Condition/Symptom

Generic Name

Comments

Brand Name

Manufacturer

Relapsing-Remitting MS, Secondary Progressive MS with relapses

Interferon Beta 1a

30 mcg intramuscular once per week self-injection

Avonex

Biogen

44 mcg subcutaneous 3 times per week self-injection

Rebif

Ares-Serono

Interferon Beta 1b

Subcutaneous self-injection once every two days

Betaseron

Berlex

Betaferon

Schering

Relapsing-Remitting MS

Glatiramer Acetate

20mg subcutaneous daily self-injection

Copaxone

Teva-Marion

Chemotherapeutic Agents

Condition/Symptom

Generic Name

Comments

Brand Name

Manufacturer

Secondary Progressive MS, Worsening Relapsing-Remitting MS

Mitoxantrone

Intravenous every 3 months for about 2 to 3 years

Novantrone

Immunex

Potential, unlicensed treatments for Secondary Progressive MS and Worsening Relapsing-Remitting MS

Azathioprine

Anti-cancer treatments - currently unlicensed for use with MS

Imuran

Glaxo-Smith-Kline

Cyclophosphamide

Anti-cancer treatments - currently unlicensed for use with MS

Cytoxan, Neosar

Bristol-Myers Squibb

Cyclosporine

Anti-cancer treatments - currently unlicensed for use with MS

Sandimmune

Novartis Pharma

Methotrexate

Anti-cancer treatments - currently unlicensed for use with MS

generic

Mylan

Cladribine

Anti-cancer treatments - currently unlicensed for use with MS

Leustatin

 

Corticosteroids & ACTH

Condition/Symptom

Generic Name

Comments

Brand Name

Manufacturer

Acute relapses in Relapsing-Remitting MS and occasionally Secondary Progressive MS

MethylPrednisolone

Intravenous high doses tapered off

Depo-Medrol

 

Solu-Medrol

Pharmacia

Prednisone

Oral administration

Deltasone

Pharmacia

Prednisolone

Intravenous administration

Delta-Cortef

Pharmacia

Dexamethasone 

 

Oral administration

Medrol

Pharmacia

Decadron

Merck

Adreno-corticotrophic Hormone (ACTH), Corticotropin

Use largely replaced by synthetic corticosteroids

Acthar

Roche, Rhone-Poulenc Rorer

Pain/Altered Sensation (Dysaesthesia)

Condition/Symptom

Generic Name

Comments

Brand Name

Manufacturer

Neuropathic/neurogenic pain (pain that arises from nerve dysfunction and not as a result of injury e.g. Trigeminal Neuralgia)

 

 

 

 

 

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Carbamazepine

Anti-convulsant

Tegretol, Epitol, Atretol, Carbatrol

Ciba

Gabapentin

Anti-convulsant

Neurontin

Pfizer

Topiramate

Anti-convulsant

Topamax

Ortho-McNeil

Zonisamide

Anti-convulsant

Zonegran

Elan

Phenytoin

 

Dilantin

 

Desipramine

 

Norpramin

 

Amitriptyline

Tricyclic antidepressant

Elavil

AstraZeneca

Imipramine

Tricyclic antidepressant

Tofranil, Imavate, Janimine

Ciba Geigy

Doxepin 

Tricyclic antidepressant

Sinequan, Adapin, Triadapin, Zonalon

 

Protriptyline

Tricyclic antidepressant

Vivactil

 

Cannabis and synthetic cannabinoids

Illegal in many parts of the world

Marinol

 

Pain associated with poor circulation

Pentoxifylline

 

Trental

 

'flu-like symptoms associated with Beta Interferon injections 
 
 
 
 

 

Ibprofen 

 

 

Neurofen 

 

US versions 

 

Aspirin 

 

generic 

 

Acetaminophen 

Often formulated with alkaloid pain killers like codeine and hydrocodone

generic

 

Paroxysmal itching

Hydroxyzine

 

Atarax

 

Depression/Anxiety/Insomnia

Condition/Symptom

Generic Name

Comments

Brand Name

Manufacturer

Depression without anxiety

Fluoxetine

SSRI

Prozac

Eli Lilly

Mild anxiety, panic attacks, people on multiple medications 

 

Sertraline

SSRI 

 

Zoloft

Pfizer

Lustral

Pfizer

Moderate depression, anxiety, people for whom other antidepressants don't work

Venlafaxine

SSRI

Effexor XR

Wyeth-Ayerst Laboratories

Depression with mild anxiety

Citalopram

SSRI

Celexa

Forest Pharmaceuticals

Depression with mild anxiety

Parocetine

SSRI

Paxil, Seroxat

Glaxo-Smith-Kline

Depression also agoraphobia,  insomnia,  essential tremor, some pain syndromes

Trazodone

Similar to SSRIs - works by increasing the amount of serotonin

Desyrel,  Trialodine

Pharmacia

Depression

Amitriptyline

Tricyclic antidepressant

Elavil

AstraZeneca

Endogenous depression 

Nortriptyline

Tricyclic antidepressant

 

Pamelor

Novartis

Aventyl

Eli Lilly

Depression

Imipramine

Tricyclic antidepressant

Tofranil, Imavate, Janimine

Ciba Geigy

Depression particularly when accompanied by anxiety and insomnia

Dothiepin 

Tricyclic antidepressant

Prothiaden

Knoll Pharmaceuticals

Depression of varying severity with coexisting anxiety

Lofepramine

Tricyclic antidepressant 

Gamanil

Organon

Anxiety, neurosis, manic depression

Doxepin 

Tricyclic antidepressant

Sinequan, Adapin, Triadapin, Zonalon

 

All types of depression, apathety, withdrawl

Protriptyline

Tricyclic antidepressant

Vivactil

 

Moderate to severe depression

Tranylcypromine

Monoamine oxidase inhibitor (MAOI)

Parnate

Glaxo-Smith-Kline

Depression particularly when accompanied by social phobia

Moclobemide

Monoamine oxidase inhibitor (MAOI)

Manerix, Aurorix

Roche

Withdrawn, depression-related fatigue, concentration and attention problems, depression-related sexual dysfunction

Bupropion

Aminoketone antidepressant

Wellbutrin SR

Glaxo-Smith-Kline

Amfebutamone

 

Depression with significant anxiety, panic attacks, insomnia, sexual dysfunction

Nefazodone

Phenylpiperazine antidepressant 

Serzone

Bristol-Myers Squibb

Depression with insomnia, moderate to severe anxiety, sexual dysfunction

Mirtazapine

Piperazino-azepine antidepressant 

Remeron

Organon

Insomnia

Zolpidem

Imidazopyridine 

Ambien

Pharmacia

Anxiety - not indicated if primary complaint is depression

Alprazolam

Benzodiazepine - addictive

Xanax

Pharmacia & Upjohn

Insomnia, Anxiety

Temazepam

Benzodiazepine - addictive

Restoril

Novartis

Anxiety, Insomnia, muscle relaxant

Diazepam

Benzodiazepine - addictive

Valium

Roche

Anxiety

Buspirone

Azaspirodecanedione

BuSpar 

Bristol-Myers Squibb

Fatigue

Condition/Symptom

Generic Name

Comments

Brand Name

Manufacturer

Multiple sclerosis fatigue. Also dystonia and akathisia

Amantadine

Anti-viral 

Symmetrel

Endo Pharmaceuticals

 Fatigue

Pemoline

Central Nervous System stimulant

Cylert

 

Modafinil

 

Provigil

 

Urinary Problems

Condition/Symptom

Generic Name

Comments

Brand Name

Manufacturer

Urinary Frequency and Urgency

Oxybutynin

 

Ditropan XL

 

Desmopressin, Vasopressin

Nasal spray

DDAVP

 

Urinary Urgency and Incontinence

 

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Tolterodine

 

Detrol

 

Carbamazepine

Anti-convulsant

Tegretol, Epitol, Atretol, Carbatrol

Ciba

Imipramine

 

Tofranil

 

Bethane

 

Urecholine

 

Urinary Hestitancy

Phenoxybenzamine

 

Dibenzyline

 

Terazosin

 

Hytrin

 

Spastic Bladder

Propantheline

Anticholinergic agent

Pro-Banthine 

 

Oxybutynin

Anticholinergic agent

Ditropan

 

Hyoscyamine

Anticholinergic agent

Urispas

 

Cystopas

 

Baclofen

Sceletal muscle relaxant 

Lioresal

 

Diazepam

Benzodiazepine - addictive

Vallium

 

Urinary Tract Infections (UTI)

Methenamine

 

Hiprex

 

Mandelamine

 

Nitrofurantoin

 

Macrodantin

 

Phenazopyridine

 

Pyridium

 

Ciprofloxacin

 

Cipro

 

Bowel Problems

Condition/Symptom

Generic Name

Comments

Brand Name

Manufacturer

Constipation

Bisacodyl

Stimulant laxative 

 

Dulcolax 

 

Bisacolax 

 

Magnesium hydroxide (Milk of Magnesia)

Hyperosmotic laxative

generic

 

Glycerin

Hyperosmotic laxative, suppository

Sani-Supp 

 

Psyllium hydrophilic mucilloid 

Bulk-forming oral laxative

Metamucil

 

Sodium phosphate 

 

Fleet Enema

 

Docusate

Stool Softener 

Colace

 

 

Suppository 

Therevac Plus

 

Sexual Dysfunction

Condition/Symptom

Generic Name